Detailed information of TA system TA138614

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2271050..2271313
• Replicon: chromosome
• Accession: NZ_CP043392
• Organism: Staphylococcus aureus strain NRS384-rpoB-H481N-NCV

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FZC50_RS11685
• Protein ID: WP_001802298.1
• Coordinates: 2271209..2271313 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2271050..2271214 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZC50_RS11665	2267233..2267898	-	666	WP_001024094.1	SDR family oxidoreductase	-
FZC50_RS11670	2268050..2268370	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FZC50_RS11675	2268372..2269352	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
FZC50_RS11680	2269618..2270709	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2271050..2271214	+	165	-	-	Antitoxin
FZC50_RS11685	2271209..2271313	-	105	WP_001802298.1	hypothetical protein	Toxin
FZC50_RS11690	2271474..2271957	-	484	Protein_2206	recombinase family protein	-
FZC50_RS11695	2272000..2273136	-	1137	WP_000115564.1	SAP domain-containing protein	-
FZC50_RS11700	2273425..2273517	+	93	WP_001790138.1	hypothetical protein	-
FZC50_RS11705	2274222..2275079	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
FZC50_RS11710	2275147..2275929	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T138614 WP_001802298.1 NZ_CP043392:c2271313-2271209 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T138614 NZ_CP058168:c56809-56393 [Enterobacter hormaechei]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTACTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCAGCGCATTGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCCCCGCGCCACATTGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCAGCCACGGACATTAAAGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGATACGCTCATTGC
CGGACACGCCATTGCCGCCGGTGCCGTACTGGTGACGAGGGACGGGGGGGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT138614 NZ_CP043392:2271050-2271214 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin