Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2592651..2593174 Replicon chromosome
Accession NZ_CP043389
Organism Staphylococcus aureus strain NRS384-rpoB-H481N-SCV

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag FZC51_RS13355 Protein ID WP_000074048.1
Coordinates 2592651..2592917 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FZC51_RS13360 Protein ID WP_000587616.1
Coordinates 2592917..2593174 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC51_RS13335 2587958..2589145 - 1188 WP_000026194.1 MFS transporter -
FZC51_RS13340 2589541..2590317 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
FZC51_RS13345 2590310..2590972 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
FZC51_RS13350 2591220..2592296 - 1077 WP_001076671.1 M42 family metallopeptidase -
FZC51_RS13355 2592651..2592917 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
FZC51_RS13360 2592917..2593174 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FZC51_RS13370 2593533..2593988 + 456 WP_000732082.1 DUF1307 domain-containing protein -
FZC51_RS13375 2594156..2595733 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
FZC51_RS13380 2595928..2596677 + 750 WP_000072444.1 hypothetical protein -
FZC51_RS13385 2596901..2598094 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T138603 WP_000074048.1 NZ_CP043389:c2592917-2592651 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T138603 NZ_CP043389:c2592917-2592651 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT138603 WP_000587616.1 NZ_CP043389:c2593174-2592917 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT138603 NZ_CP058164:c4629136-4628846 [Enterobacter hormaechei]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATCAACGAAATTGCCGAGGGCCAACGAGAGCCGTC
GCGTACGTTTCAAATTGATGCGATGAAAATAAAAGAAATTCGTCAGGCGTCCGGGTTGTCGCAGAGTAAATTCGCGAACT
TAATCTCAGTTAGCGTTGATACGTTGCGTAACTGGGAACAAGGCAGACGCTCACCTACAGGCCCCGCTAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCCCAGCCCTAACGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References