Detailed information of TA system TA138576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2096428..2096727
• Replicon: chromosome
• Accession: NZ_CP043386
• Organism: Staphylococcus aureus strain NRS384

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FZC49_RS10680
• Protein ID: WP_011447039.1
• Coordinates: 2096551..2096727 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2096428..2096483 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZC49_RS10635	2091759..2092019	+	261	WP_001791826.1	hypothetical protein	-
FZC49_RS10640	2092072..2092422	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FZC49_RS10645	2093107..2093556	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FZC49_RS10650	2093651..2093986	-	336	Protein_2007	SH3 domain-containing protein	-
FZC49_RS10660	2094636..2095127	-	492	WP_000919350.1	staphylokinase	-
FZC49_RS10665	2095318..2096073	-	756	WP_000861038.1	CHAP domain-containing protein	-
FZC49_RS10670	2096085..2096339	-	255	WP_000611512.1	phage holin	-
FZC49_RS10675	2096391..2096498	+	108	WP_001791821.1	hypothetical protein	-
-	2096420..2096559	+	140	NuclAT_0	-	-
-	2096420..2096559	+	140	NuclAT_0	-	-
-	2096420..2096559	+	140	NuclAT_0	-	-
-	2096420..2096559	+	140	NuclAT_0	-	-
-	2096428..2096483	+	56	-	-	Antitoxin
FZC49_RS10680	2096551..2096727	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FZC49_RS10685	2096877..2097173	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FZC49_RS10690	2097231..2097518	-	288	WP_001040261.1	hypothetical protein	-
FZC49_RS10695	2097565..2097717	-	153	WP_001153681.1	hypothetical protein	-
FZC49_RS10700	2097707..2101492	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2092072..2148020	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T138576 WP_011447039.1 NZ_CP043386:c2096727-2096551 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T138576 NZ_CP058158:c112704-112219 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT138576 NZ_CP043386:2096428-2096483 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin