Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3537720..3538377 Replicon chromosome
Accession NZ_CP043382
Organism Enterobacter hormaechei subsp. xiangfangensis strain WCHEX045001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EKN98_RS17415 Protein ID WP_032609983.1
Coordinates 3538078..3538377 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EKN98_RS17410 Protein ID WP_032609984.1
Coordinates 3537720..3538067 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN98_RS17385 3533054..3534052 + 999 WP_022651706.1 transketolase family protein -
EKN98_RS17390 3534127..3534858 + 732 WP_042863460.1 class I SAM-dependent methyltransferase -
EKN98_RS17395 3534855..3535457 - 603 WP_022651704.1 short chain dehydrogenase -
EKN98_RS17400 3535555..3536442 + 888 WP_022651703.1 LysR family transcriptional regulator -
EKN98_RS17405 3536463..3537644 + 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
EKN98_RS17410 3537720..3538067 - 348 WP_032609984.1 HigA family addiction module antidote protein Antitoxin
EKN98_RS17415 3538078..3538377 - 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EKN98_RS17420 3538628..3539788 - 1161 WP_087920848.1 HlyD family efflux transporter periplasmic adaptor subunit -
EKN98_RS17425 3539808..3542000 - 2193 WP_032609980.1 type I secretion system permease/ATPase -
EKN98_RS17430 3541997..3542704 - 708 Protein_3351 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3535555..3556543 20988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T138563 WP_032609983.1 NZ_CP043382:c3538377-3538078 [Enterobacter hormaechei subsp. xiangfangensis]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T138563 NZ_CP058153:c4650107-4649736 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT138563 WP_032609984.1 NZ_CP043382:c3538067-3537720 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT138563 NZ_CP058153:c4650352-4650110 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References