Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 328018..328604 Replicon chromosome
Accession NZ_CP043362
Organism Klebsiella pneumoniae strain WCHKP085104

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag B7D52_RS01530 Protein ID WP_002920800.1
Coordinates 328236..328604 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag B7D52_RS01525 Protein ID WP_071081456.1
Coordinates 328018..328239 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B7D52_RS01505 (324175) 324175..325101 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
B7D52_RS01510 (325098) 325098..326375 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
B7D52_RS01515 (326372) 326372..327139 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
B7D52_RS01520 (327141) 327141..327854 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
B7D52_RS01525 (328018) 328018..328239 + 222 WP_071081456.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B7D52_RS01530 (328236) 328236..328604 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
B7D52_RS01535 (328877) 328877..330193 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
B7D52_RS01540 (330300) 330300..331187 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
B7D52_RS01545 (331184) 331184..332029 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
B7D52_RS01550 (332031) 332031..333101 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 325098..333838 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T138517 WP_002920800.1 NZ_CP043362:328236-328604 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T138517 NZ_CP043362:328236-328604 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT138517 WP_071081456.1 NZ_CP043362:328018-328239 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHSDEIRELADK

Download         Length: 222 bp

>AT138517 NZ_CP043362:328018-328239 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATAGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure

References