138506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 40629..40898 Replicon plasmid pKPC2_020120
Accession NZ_CP043358
Organism Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020120

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag CLQ78_RS27135 Protein ID WP_001372321.1
Coordinates 40773..40898 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 40629..40694 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ78_RS27110 36339..36866 + 528 WP_000290834.1 single-stranded DNA-binding protein -
CLQ78_RS27115 36924..37157 + 234 WP_000006003.1 DUF905 family protein -
CLQ78_RS27120 37218..39241 + 2024 Protein_49 ParB/RepB/Spo0J family partition protein -
CLQ78_RS27125 39310..39744 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
CLQ78_RS27130 39741..40460 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 40472..40696 + 225 NuclAT_0 - -
- 40472..40696 + 225 NuclAT_0 - -
- 40472..40696 + 225 NuclAT_0 - -
- 40472..40696 + 225 NuclAT_0 - -
- 40629..40694 + 66 - - Antitoxin
CLQ78_RS29310 40682..40831 + 150 Protein_52 plasmid maintenance protein Mok -
CLQ78_RS27135 40773..40898 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
CLQ78_RS27140 41217..41513 - 297 Protein_54 hypothetical protein -
CLQ78_RS27145 41813..42109 + 297 WP_001272251.1 hypothetical protein -
CLQ78_RS27150 42220..43041 + 822 WP_001234445.1 DUF932 domain-containing protein -
CLQ78_RS27155 43338..43985 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
CLQ78_RS27160 44262..44645 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
CLQ78_RS27165 44836..45522 + 687 WP_015059009.1 PAS domain-containing protein -
CLQ78_RS27170 45616..45843 + 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB - 1..154719 154719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T138506 WP_001372321.1 NZ_CP043358:40773-40898 [Klebsiella pneumoniae subsp. pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp

>T138506 NZ_CP043358:40773-40898 [Klebsiella pneumoniae subsp. pneumoniae]
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 66 bp

>AT138506 NZ_CP043358:40629-40694 [Klebsiella pneumoniae subsp. pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References