Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 40629..40898 | Replicon | plasmid pKPC2_020120 |
Accession | NZ_CP043358 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020120 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | CLQ78_RS27135 | Protein ID | WP_001372321.1 |
Coordinates | 40773..40898 (+) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 40629..40694 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CLQ78_RS27110 | 36339..36866 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
CLQ78_RS27115 | 36924..37157 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
CLQ78_RS27120 | 37218..39241 | + | 2024 | Protein_49 | ParB/RepB/Spo0J family partition protein | - |
CLQ78_RS27125 | 39310..39744 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
CLQ78_RS27130 | 39741..40460 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- | 40472..40696 | + | 225 | NuclAT_0 | - | - |
- | 40472..40696 | + | 225 | NuclAT_0 | - | - |
- | 40472..40696 | + | 225 | NuclAT_0 | - | - |
- | 40472..40696 | + | 225 | NuclAT_0 | - | - |
- | 40629..40694 | + | 66 | - | - | Antitoxin |
CLQ78_RS29310 | 40682..40831 | + | 150 | Protein_52 | plasmid maintenance protein Mok | - |
CLQ78_RS27135 | 40773..40898 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
CLQ78_RS27140 | 41217..41513 | - | 297 | Protein_54 | hypothetical protein | - |
CLQ78_RS27145 | 41813..42109 | + | 297 | WP_001272251.1 | hypothetical protein | - |
CLQ78_RS27150 | 42220..43041 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
CLQ78_RS27155 | 43338..43985 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
CLQ78_RS27160 | 44262..44645 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
CLQ78_RS27165 | 44836..45522 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
CLQ78_RS27170 | 45616..45843 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB | - | 1..154719 | 154719 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T138506 WP_001372321.1 NZ_CP043358:40773-40898 [Klebsiella pneumoniae subsp. pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T138506 NZ_CP043358:40773-40898 [Klebsiella pneumoniae subsp. pneumoniae]
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 66 bp
>AT138506 NZ_CP043358:40629-40694 [Klebsiella pneumoniae subsp. pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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