Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 127518..127771 | Replicon | plasmid pKPC2_020039 |
| Accession | NZ_CP043345 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WCHKP020039 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | CVC44_RS27305 | Protein ID | WP_001312851.1 |
| Coordinates | 127622..127771 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 127518..127577 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CVC44_RS27260 (122573) | 122573..122785 | - | 213 | WP_014343500.1 | hypothetical protein | - |
| CVC44_RS27265 (122846) | 122846..123202 | - | 357 | WP_014343501.1 | hypothetical protein | - |
| CVC44_RS27270 (123296) | 123296..124000 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| CVC44_RS27275 (124025) | 124025..124225 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| CVC44_RS27280 (124245) | 124245..124991 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| CVC44_RS27285 (125046) | 125046..125606 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| CVC44_RS27290 (125738) | 125738..125938 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| CVC44_RS27295 (126324) | 126324..126923 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| CVC44_RS27300 (126985) | 126985..127317 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (127518) | 127518..127577 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (127518) | 127518..127577 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (127518) | 127518..127577 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (127518) | 127518..127577 | - | 60 | NuclAT_1 | - | Antitoxin |
| CVC44_RS27305 (127622) | 127622..127771 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| CVC44_RS27310 (128055) | 128055..128303 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaKPC-2 / blaSHV-12 | - | 1..128614 | 128614 | |
| - | flank | IS/Tn | - | - | 123296..124000 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T138443 WP_001312851.1 NZ_CP043345:127622-127771 [Klebsiella pneumoniae subsp. pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T138443 NZ_CP057896:c572200-571991 [Escherichia fergusonii]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 60 bp
>AT138443 NZ_CP043345:c127577-127518 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
