Detailed information of TA system TA138403

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 49267..49536
• Replicon: plasmid p3_115106
• Accession: NZ_CP043338
• Organism: Escherichia coli strain WCHEC115106

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: FZC46_RS25260
• Protein ID: WP_001372321.1
• Coordinates: 49411..49536 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	49267..49332 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZC46_RS25220	44269..44511	+	243	WP_001365577.1	hypothetical protein	-
FZC46_RS25225	44981..45508	+	528	WP_000290793.1	single-stranded DNA-binding protein	-
FZC46_RS25230	45564..45797	+	234	WP_000006004.1	DUF905 domain-containing protein	-
FZC46_RS25235	45856..47879	+	2024	Protein_56	ParB/RepB/Spo0J family partition protein	-
FZC46_RS25240	47948..48382	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
FZC46_RS25245	48379..49141	+	763	Protein_58	plasmid SOS inhibition protein A	-
-	49110..49334	+	225	NuclAT_0	-	-
-	49110..49334	+	225	NuclAT_0	-	-
-	49110..49334	+	225	NuclAT_0	-	-
-	49110..49334	+	225	NuclAT_0	-	-
FZC46_RS25250	49119..49298	-	180	WP_001309233.1	hypothetical protein	-
-	49267..49332	+	66	-	-	Antitoxin
FZC46_RS25255	49320..49469	+	150	Protein_60	plasmid maintenance protein Mok	-
FZC46_RS25260	49411..49536	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
FZC46_RS25265	49855..50151	-	297	Protein_62	hypothetical protein	-
FZC46_RS25270	50451..50747	+	297	WP_001272251.1	hypothetical protein	-
FZC46_RS25275	50858..51679	+	822	WP_001234445.1	DUF932 domain-containing protein	-
FZC46_RS25280	51976..52566	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
FZC46_RS25285	52901..53284	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
FZC46_RS25290	53478..54149	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
FZC46_RS25295	54286..54513	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T138403 WP_001372321.1 NZ_CP043338:49411-49536 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T138403 NZ_CP043338:49411-49536 [Escherichia coli]
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT138403 NZ_CP043338:49267-49332 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Structures

Antitoxin