Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 56199..56453 | Replicon | plasmid p1_115106 |
| Accession | NZ_CP043336 | ||
| Organism | Escherichia coli strain WCHEC115106 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | FZC46_RS23955 | Protein ID | WP_001312851.1 |
| Coordinates | 56199..56348 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 56392..56453 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FZC46_RS23920 (52220) | 52220..52720 | + | 501 | Protein_60 | Tn3 family transposase | - |
| FZC46_RS23925 (52754) | 52754..52942 | + | 189 | Protein_61 | IS3 family transposase | - |
| FZC46_RS23930 (53017) | 53017..53304 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FZC46_RS23935 (53301) | 53301..53552 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FZC46_RS23940 (54518) | 54518..55375 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| FZC46_RS23945 (55368) | 55368..55442 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| FZC46_RS23950 (55674) | 55674..55931 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| FZC46_RS23955 (56199) | 56199..56348 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (56392) | 56392..56453 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (56392) | 56392..56453 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (56392) | 56392..56453 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (56392) | 56392..56453 | + | 62 | NuclAT_1 | - | Antitoxin |
| FZC46_RS23960 (56795) | 56795..57007 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| FZC46_RS23965 (57142) | 57142..57702 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| FZC46_RS23970 (57757) | 57757..58209 | - | 453 | WP_241420250.1 | type-F conjugative transfer system pilin acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / tet(A) / lnu(F) / blaTEM-1B / sul3 / aph(3')-Ia / aac(3)-IId | - | 1..133446 | 133446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T138394 WP_001312851.1 NZ_CP043336:c56348-56199 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T138394 NZ_CP057681:3331408-3331698 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACGAAATTA
AGCTTCGCACACTGGGATATCGCCGGGTCTATCAGGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACGAAATTA
AGCTTCGCACACTGGGATATCGCCGGGTCTATCAGGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA
Antitoxin
Download Length: 62 bp
>AT138394 NZ_CP043336:56392-56453 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
