Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1473245..1473860 Replicon chromosome
Accession NZ_CP043320
Organism Pseudomonas sp. C27(2019)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FXF61_RS06750 Protein ID WP_151186028.1
Coordinates 1473245..1473583 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FXF61_RS06755 Protein ID WP_151184551.1
Coordinates 1473564..1473860 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXF61_RS06725 1468940..1469464 - 525 WP_151184547.1 rhodanese family protein -
FXF61_RS06730 1469620..1470219 - 600 WP_151184548.1 recombination mediator RecR -
FXF61_RS06735 1470335..1470658 - 324 WP_151184549.1 YbaB/EbfC family nucleoid-associated protein -
FXF61_RS06740 1470669..1472801 - 2133 WP_151184550.1 DNA polymerase III subunit gamma/tau -
FXF61_RS06750 1473245..1473583 + 339 WP_151186028.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXF61_RS06755 1473564..1473860 + 297 WP_151184551.1 helix-turn-helix domain-containing protein Antitoxin
FXF61_RS06760 1473934..1474179 - 246 WP_151184552.1 formate dehydrogenase subunit delta -
FXF61_RS06765 1474176..1475060 - 885 WP_151184553.1 formate dehydrogenase accessory sulfurtransferase FdhD -
FXF61_RS06770 1475041..1477995 - 2955 WP_151184554.1 formate dehydrogenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12981.16 Da        Isoelectric Point: 10.0299

>T138352 WP_151186028.1 NZ_CP043320:1473245-1473583 [Pseudomonas sp. C27(2019)]
ITWKVCFYPGTEEQFLQMPNKIQARMLKLLELMEKHGANLGYPHTEAISGGLFEIRAKATEGIGRALFCYLKGQHIYVLH
AFVKKTQKTPRKDLDLARQRQKEVKNYELTNT

Download         Length: 339 bp

>T138352 NZ_CP043320:1473245-1473583 [Pseudomonas sp. C27(2019)]
ATAACATGGAAAGTCTGCTTTTATCCGGGCACTGAAGAGCAGTTTCTTCAAATGCCAAATAAAATCCAAGCTCGAATGTT
AAAACTACTTGAACTGATGGAAAAACATGGCGCTAATCTCGGATATCCTCACACCGAAGCAATCAGCGGTGGTTTATTTG
AGATTAGAGCTAAAGCTACAGAAGGTATCGGTCGCGCGCTGTTTTGCTACTTAAAAGGTCAACACATCTATGTTCTTCAT
GCTTTTGTAAAAAAGACACAGAAAACACCTAGAAAAGACTTAGATCTTGCACGTCAACGCCAAAAAGAGGTCAAAAACTA
TGAACTTACAAACACTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11097.61 Da        Isoelectric Point: 8.0034

>AT138352 WP_151184551.1 NZ_CP043320:1473564-1473860 [Pseudomonas sp. C27(2019)]
MNLQTLKQRALANPDVKTEYDKLDAEFELIDHLISMRSQAGLTQEQLAERMSTQKSNISRLERGNSNPSWATLVKYANAC
GFELLLKAQKKNLTAQTE

Download         Length: 297 bp

>AT138352 NZ_CP043320:1473564-1473860 [Pseudomonas sp. C27(2019)]
ATGAACTTACAAACACTTAAACAACGCGCCCTAGCCAACCCTGATGTGAAAACTGAATACGATAAATTAGATGCTGAATT
TGAGCTTATCGATCATTTGATTTCTATGCGCAGCCAAGCAGGCTTAACTCAAGAGCAACTGGCTGAGCGTATGAGCACAC
AAAAAAGCAATATCAGCCGATTGGAGCGCGGCAATAGCAACCCCAGTTGGGCGACTTTAGTTAAATATGCAAATGCTTGC
GGGTTTGAATTGCTGCTCAAAGCGCAAAAGAAAAACCTAACAGCTCAGACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References