Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 6287894..6288408 Replicon chromosome
Accession NZ_CP043317
Organism Streptomyces olivaceus strain SCSIO T05

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6G9ES44
Locus tag FYC74_RS27060 Protein ID WP_031030578.1
Coordinates 6287894..6288148 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6G9ESD1
Locus tag FYC74_RS27065 Protein ID WP_031030581.1
Coordinates 6288145..6288408 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYC74_RS27040 6284113..6284781 + 669 WP_194277959.1 DUF3105 domain-containing protein -
FYC74_RS27045 6284778..6285407 + 630 WP_194277960.1 DUF305 domain-containing protein -
FYC74_RS27050 6285545..6287335 + 1791 WP_194277961.1 NAD+ synthase -
FYC74_RS27055 6287363..6287809 - 447 WP_194277962.1 VOC family protein -
FYC74_RS27060 6287894..6288148 - 255 WP_031030578.1 Txe/YoeB family addiction module toxin Toxin
FYC74_RS27065 6288145..6288408 - 264 WP_031030581.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FYC74_RS27070 6288560..6291571 + 3012 WP_194277963.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
FYC74_RS27075 6291813..6292673 - 861 WP_194277964.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9911.23 Da        Isoelectric Point: 9.7377

>T138333 WP_031030578.1 NZ_CP043317:c6288148-6287894 [Streptomyces olivaceus]
VRVTFTSHGWEDYVHWAESDRKVTKRINRLIDDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADGVLVIVQA
RYHY

Download         Length: 255 bp

>T138333 NZ_CP057611:755992-756399 [Citrobacter sp. RHB21-C05]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCGTGGCGCGCGCAGTGGTTGTCGCTGCTCCTGCATGGGCTGGTGGCCGC
GGCGATTTTGTTAATGCCCTGGCCGCTGAGCTACACCCCGCTGTGGATGATTTTACTGTCGCTGGTGGTGTTTGACTGCG
TCCGCAGTCAGCGTCGAATAAACACCTGTCAGGGCGAGGTGAAACTGCTACTGGACGGTCGGCTTCGCTGGCAAGGGCGT
GAATGGACAATCGTCAGCGCGCCCTGGATCATCAAAACCGGCATGATGTTGCGCCTGCGTTCAGAAAGCGGGAAGCGCCA
GCATTTGTGGCTTGCAGCGGACAGCATGGATGAAGCGGAGTGGCGGGATTTATGTCGGCTGATGCTGCAACAGTCAATGC
AACGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9784.92 Da        Isoelectric Point: 4.8784

>AT138333 WP_031030581.1 NZ_CP043317:c6288408-6288145 [Streptomyces olivaceus]
MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT138333 NZ_CP057611:755745-756011 [Citrobacter sp. RHB21-C05]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCATGCCGTCGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGATACGTTAAGCGATGATGAAAAACGCATTTTTGTCCGTCTGCTGGAATGCGACGATCCCGATT
TATTCAACTGGTTAATGAACCACGGTAAACCAGCGGATGTTGAGCTGGAACAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9ES44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9ESD1

References