Detailed information of TA system TA138318

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2806608..2806790
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: FQP84_RS14490
• Protein ID: WP_001801861.1
• Coordinates: 2806608..2806703 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2806731..2806790 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS14440	2802268..2802894	+	627	WP_000669046.1	hypothetical protein	-
FQP84_RS14445	2802935..2803279	+	345	WP_000627551.1	DUF3969 family protein	-
FQP84_RS14450	2803377..2803928	+	552	WP_000414205.1	hypothetical protein	-
FQP84_RS14455	2804146..2804787	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
FQP84_RS14460	2804901..2805086	-	186	WP_000809857.1	hypothetical protein	-
FQP84_RS14465	2805088..2805264	-	177	WP_000375476.1	hypothetical protein	-
FQP84_RS14470	2805275..2805658	-	384	WP_000070811.1	hypothetical protein	-
FQP84_RS14480	2806262..2806405	-	144	WP_001549059.1	transposase	-
FQP84_RS14490	2806608..2806703	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2806731..2806790	-	60	-	-	Antitoxin
FQP84_RS14495	2806826..2806927	+	102	WP_001791893.1	hypothetical protein	-
FQP84_RS14500	2806905..2807081	-	177	Protein_2791	transposase	-
FQP84_RS14505	2807275..2807652	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	2779841..2839881	60040
	-	flank	IS/Tn	-	-	2801570..2802055	485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T138318 WP_001801861.1 NZ_CP043302:2806608-2806703 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T138318 NZ_CP057565:982497-982649 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT138318 NZ_CP043302:c2806790-2806731 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin