Detailed information of TA system TA138314

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1944572..1944910
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FQP84_RS10065
• Protein ID: WP_011447039.1
• Coordinates: 1944572..1944748 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1944736..1944910 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS10045	1942402..1942554	+	153	WP_001000058.1	hypothetical protein	-
FQP84_RS10050	1942600..1942887	+	288	WP_001262621.1	hypothetical protein	-
FQP84_RS10055	1942943..1943317	+	375	WP_000340977.1	hypothetical protein	-
FQP84_RS10060	1943690..1944463	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
FQP84_RS10065	1944572..1944748	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1944736..1944910	-	175	-	-	Antitoxin
FQP84_RS10075	1944960..1945214	+	255	WP_000611512.1	phage holin	-
FQP84_RS10080	1945226..1945981	+	756	WP_000861038.1	CHAP domain-containing protein	-
FQP84_RS10085	1946172..1946663	+	492	WP_000920038.1	staphylokinase	-
FQP84_RS10105	1947314..1947649	+	336	Protein_1930	SH3 domain-containing protein	-
FQP84_RS10110	1948160..1948510	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
FQP84_RS10115	1948563..1948823	-	261	WP_001791826.1	hypothetical protein	-
FQP84_RS10125	1949134..1949313	-	180	WP_000669791.1	hypothetical protein	-
FQP84_RS10130	1949635..1949885	-	251	Protein_1934	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sea / sak / scn	1892361..1948510	56149

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T138314 WP_011447039.1 NZ_CP043302:1944572-1944748 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T138314 NZ_CP057563:c63799-63419 [Escherichia fergusonii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGACTCCCCTGAACTGGTAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTACTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT138314 NZ_CP043302:c1944910-1944736 [Staphylococcus aureus]
ATTTGATCTTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin