Detailed information of TA system TA138309

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1765421..1765700
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FQP84_RS09050
• Protein ID: WP_001802298.1
• Coordinates: 1765421..1765525 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1765521..1765700 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS09025	1760805..1761587	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
FQP84_RS09030	1761655..1762512	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
FQP84_RS09035	1763217..1763309	-	93	WP_001790138.1	hypothetical protein	-
FQP84_RS09040	1763598..1764734	+	1137	WP_000115564.1	SAP domain-containing protein	-
FQP84_RS09045	1764777..1765260	+	484	Protein_1730	recombinase family protein	-
FQP84_RS09050	1765421..1765525	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1765521..1765700	-	180	-	-	Antitoxin
FQP84_RS09055	1765968..1767059	-	1092	WP_000495671.1	lytic regulatory protein	-
FQP84_RS09060	1767325..1768305	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
FQP84_RS09065	1768307..1768627	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FQP84_RS09070	1768779..1769444	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T138309 WP_001802298.1 NZ_CP043302:1765421-1765525 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T138309 NZ_CP057561:c4269534-4269427 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT138309 NZ_CP043302:c1765700-1765521 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin