Detailed information of TA system TA138307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1500222..1500739
• Replicon: chromosome
• Accession: NZ_CP043302
• Organism: Staphylococcus aureus strain 16445

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: FQP84_RS07660
• Protein ID: WP_000113262.1
• Coordinates: 1500473..1500739 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: FQP84_RS07655
• Protein ID: WP_000584499.1
• Coordinates: 1500222..1500473 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQP84_RS07625	1495920..1496639	+	720	WP_149590278.1	amino acid ABC transporter permease	-
FQP84_RS07630	1496636..1497367	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
FQP84_RS07635	1497464..1498714	-	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
FQP84_RS07640	1498969..1499331	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
FQP84_RS07645	1499350..1499949	+	600	WP_000162813.1	DsbA family protein	-
FQP84_RS07650	1499956..1500057	+	102	WP_031806924.1	hypothetical protein	-
FQP84_RS07655	1500222..1500473	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FQP84_RS07660	1500473..1500739	+	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
FQP84_RS07665	1500774..1500845	+	72	Protein_1465	hypothetical protein	-
FQP84_RS07670	1501034..1502584	+	1551	WP_000727762.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
FQP84_RS07675	1502770..1503237	+	468	WP_000153344.1	SRPBCC domain-containing protein	-
FQP84_RS07680	1503321..1503503	+	183	WP_000230294.1	hypothetical protein	-
FQP84_RS07685	1503720..1504544	+	825	WP_000572040.1	formate/nitrite transporter family protein	-
FQP84_RS07690	1504777..1505313	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T138307 WP_000113262.1 NZ_CP043302:1500473-1500739 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T138307 NZ_CP057561:c3466808-3466410 [Escherichia fergusonii]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGACAAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTTGCGATGCACTCTATGACGACTTGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAAAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACA
AATGACGAAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT138307 WP_000584499.1 NZ_CP043302:1500222-1500473 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT138307 NZ_CP043302:1500222-1500473 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60