Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 4600031..4600533 | Replicon | chromosome |
| Accession | NZ_CP043295 | ||
| Organism | Escherichia coli strain WCHEC040047 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | FYK54_RS22025 | Protein ID | WP_000767829.1 |
| Coordinates | 4600279..4600533 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | FYK54_RS22020 | Protein ID | WP_001259255.1 |
| Coordinates | 4600031..4600282 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK54_RS21995 (4595209) | 4595209..4596276 | - | 1068 | WP_000080136.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| FYK54_RS22000 (4596276) | 4596276..4597346 | - | 1071 | WP_000108937.1 | histidinol-phosphate transaminase | - |
| FYK54_RS22005 (4597343) | 4597343..4598647 | - | 1305 | WP_021523144.1 | histidinol dehydrogenase | - |
| FYK54_RS22010 (4598653) | 4598653..4599552 | - | 900 | WP_021523143.1 | ATP phosphoribosyltransferase | - |
| FYK54_RS22015 (4599698) | 4599698..4599748 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| FYK54_RS22020 (4600031) | 4600031..4600282 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| FYK54_RS22025 (4600279) | 4600279..4600533 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| FYK54_RS22030 (4600616) | 4600616..4601440 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| FYK54_RS22035 (4601486) | 4601486..4602415 | + | 930 | WP_023154044.1 | LysR substrate-binding domain-containing protein | - |
| FYK54_RS22040 (4602630) | 4602630..4602692 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| FYK54_RS22045 (4602682) | 4602682..4604040 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| FYK54_RS22050 (4604219) | 4604219..4605277 | + | 1059 | WP_000492324.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| FYK54_RS22055 (4605291) | 4605291..4605518 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T138282 WP_000767829.1 NZ_CP043295:4600279-4600533 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T138282 NZ_CP057506:c2314706-2314224 [Citrobacter freundii]
ATGGAAATAAACGTCACGGCGCCGGCGTTGCTGACCGAAGGGCATGAGCTGCAGCCATTCGATTGCGGTAATGAGGTGTT
AAATGATTGGCTACGTCGCCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTGGAGTCTA
CTCAGCGCGTAGTGGGTTACTATTCCATTGCAACTGGATCCGTGAGCCACGCTGACTTAGGGCGTAGTTTACGTCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTCTGTTGGGCCGTCTTGCTGTTGATGCCAGTACGCAAGGTCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTACTGCGCATTTCCAACTTAGCCGATCAAGTGGGTATCAAAGCCATCATGGTACATGCTATTG
ATGGCAAGGCCAGAGCGTTCTATGAATATTTCGGTTTCGTTCAGTCCCCAATAGCGGCAAATACGTTGTTCTACAAAATT
TAA
ATGGAAATAAACGTCACGGCGCCGGCGTTGCTGACCGAAGGGCATGAGCTGCAGCCATTCGATTGCGGTAATGAGGTGTT
AAATGATTGGCTACGTCGCCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTGGAGTCTA
CTCAGCGCGTAGTGGGTTACTATTCCATTGCAACTGGATCCGTGAGCCACGCTGACTTAGGGCGTAGTTTACGTCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTCTGTTGGGCCGTCTTGCTGTTGATGCCAGTACGCAAGGTCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTACTGCGCATTTCCAACTTAGCCGATCAAGTGGGTATCAAAGCCATCATGGTACATGCTATTG
ATGGCAAGGCCAGAGCGTTCTATGAATATTTCGGTTTCGTTCAGTCCCCAATAGCGGCAAATACGTTGTTCTACAAAATT
TAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT138282 WP_001259255.1 NZ_CP043295:4600031-4600282 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT138282 NZ_CP057506:c2314993-2314697 [Citrobacter freundii]
ATGGAGAAACTTATGCAAACCAGCGCTCGTAAGCCAACTCGCGATAAGCAAATTAATATCCGCGCTACTGATGAGGAACG
CGCAGTGATTGATTATGCCGCAAGTTTGGTTAATAAAAACCGCACTGACTTTATCATTGAGAAGGCCGTGCATGAGGCCC
AGAATATCATTCTGGATCAGCGTGTGTTCGTCCTGGACGATACCCGATATCAGTCTTTCATTGAGCAGCTTGAAGCGCCT
GTACAAAATGTTGAGGGGCGTCAACGCCTGATGGATGTGAAGCCAGAATGGAAATAA
ATGGAGAAACTTATGCAAACCAGCGCTCGTAAGCCAACTCGCGATAAGCAAATTAATATCCGCGCTACTGATGAGGAACG
CGCAGTGATTGATTATGCCGCAAGTTTGGTTAATAAAAACCGCACTGACTTTATCATTGAGAAGGCCGTGCATGAGGCCC
AGAATATCATTCTGGATCAGCGTGTGTTCGTCCTGGACGATACCCGATATCAGTCTTTCATTGAGCAGCTTGAAGCGCCT
GTACAAAATGTTGAGGGGCGTCAACGCCTGATGGATGTGAAGCCAGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|