Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3366865..3367558 Replicon chromosome
Accession NZ_CP043295
Organism Escherichia coli strain WCHEC040047

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYK54_RS16150 Protein ID WP_000415584.1
Coordinates 3366865..3367161 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYK54_RS16155 Protein ID WP_000650107.1
Coordinates 3367163..3367558 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK54_RS16115 (3361953) 3361953..3362267 - 315 WP_000958598.1 putative quinol monooxygenase -
FYK54_RS16120 (3362298) 3362298..3362879 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYK54_RS16125 (3363198) 3363198..3363530 + 333 WP_023149630.1 DUF2645 family protein -
FYK54_RS16130 (3363576) 3363576..3364925 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
FYK54_RS16135 (3364922) 3364922..3365581 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
FYK54_RS16140 (3365733) 3365733..3366125 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYK54_RS16145 (3366178) 3366178..3366660 + 483 WP_000183505.1 GyrI-like domain-containing protein -
FYK54_RS16150 (3366865) 3366865..3367161 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYK54_RS16155 (3367163) 3367163..3367558 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYK54_RS16160 (3367691) 3367691..3369298 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYK54_RS16165 (3369436) 3369436..3371694 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T138277 WP_000415584.1 NZ_CP043295:3366865-3367161 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T138277 NZ_CP043295:3366865-3367161 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT138277 WP_000650107.1 NZ_CP043295:3367163-3367558 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT138277 NZ_CP043295:3367163-3367558 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References