Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2426287..2426889 Replicon chromosome
Accession NZ_CP043295
Organism Escherichia coli strain WCHEC040047

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag FYK54_RS11650 Protein ID WP_000897305.1
Coordinates 2426578..2426889 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYK54_RS11645 Protein ID WP_000356395.1
Coordinates 2426287..2426577 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK54_RS11615 (2421910) 2421910..2422812 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
FYK54_RS11620 (2422809) 2422809..2423444 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
FYK54_RS11625 (2423441) 2423441..2424370 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
FYK54_RS11630 (2424552) 2424552..2424794 - 243 WP_021523315.1 hypothetical protein -
FYK54_RS11635 (2425013) 2425013..2425231 - 219 WP_001295676.1 CopG family transcriptional regulator -
FYK54_RS11640 (2425650) 2425650..2425928 - 279 WP_001306650.1 hypothetical protein -
FYK54_RS11645 (2426287) 2426287..2426577 - 291 WP_000356395.1 NadS family protein Antitoxin
FYK54_RS11650 (2426578) 2426578..2426889 - 312 WP_000897305.1 hypothetical protein Toxin
FYK54_RS11655 (2427118) 2427118..2428026 + 909 WP_001306651.1 alpha/beta hydrolase -
FYK54_RS11660 (2428195) 2428195..2429109 - 915 WP_077634137.1 transposase -
FYK54_RS11665 (2429122) 2429122..2430009 - 888 Protein_2279 hypothetical protein -
FYK54_RS11670 (2430425) 2430425..2431366 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
FYK54_RS11675 (2431411) 2431411..2431848 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T138275 WP_000897305.1 NZ_CP043295:c2426889-2426578 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T138275 NZ_CP057505:c4188732-4188625 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT138275 WP_000356395.1 NZ_CP043295:c2426577-2426287 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT138275 NZ_CP057505:4188790-4188844 [Escherichia fergusonii]
CAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References