Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 71179..71432 Replicon plasmid p2_025985
Accession NZ_CP043289
Organism Escherichia coli strain WCHEC025985

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag FYK42_RS25935 Protein ID WP_001312851.1
Coordinates 71283..71432 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 71179..71238 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK42_RS25900 (66955) 66955..67815 + 861 WP_000704523.1 alpha/beta hydrolase -
FYK42_RS25905 (67918) 67918..68478 + 561 WP_000139321.1 fertility inhibition protein FinO -
FYK42_RS25910 (68607) 68607..68819 + 213 WP_001309245.1 ANR family transcriptional regulator -
FYK42_RS25915 (69064) 69064..69525 + 462 WP_001233838.1 thermonuclease family protein -
FYK42_RS25920 (69571) 69571..69780 + 210 WP_001298565.1 hemolysin expression modulator Hha -
FYK42_RS25925 (69818) 69818..70408 + 591 WP_033807967.1 DUF2726 domain-containing protein -
FYK42_RS25930 (70563) 70563..71036 + 474 WP_016240489.1 hypothetical protein -
- (71179) 71179..71238 - 60 NuclAT_1 - Antitoxin
- (71179) 71179..71238 - 60 NuclAT_1 - Antitoxin
- (71179) 71179..71238 - 60 NuclAT_1 - Antitoxin
- (71179) 71179..71238 - 60 NuclAT_1 - Antitoxin
FYK42_RS25935 (71283) 71283..71432 + 150 WP_001312851.1 Hok/Gef family protein Toxin
FYK42_RS25940 (71717) 71717..71965 + 249 WP_000083839.1 replication regulatory protein RepA -
FYK42_RS25945 (72080) 72080..72264 + 185 Protein_92 protein CopA/IncA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) - 1..72276 72276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T138262 WP_001312851.1 NZ_CP043289:71283-71432 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T138262 NZ_CP057504:1911852-1911955 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 60 bp

>AT138262 NZ_CP043289:c71238-71179 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References