Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 85626..86052 | Replicon | plasmid pCTXM55_025985 |
| Accession | NZ_CP043286 | ||
| Organism | Escherichia coli strain WCHEC025985 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | FYK42_RS24525 | Protein ID | WP_001372321.1 |
| Coordinates | 85626..85751 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 85828..86052 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK42_RS24485 (81000) | 81000..81689 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| FYK42_RS24490 (81876) | 81876..82259 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| FYK42_RS24495 (82580) | 82580..83182 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| FYK42_RS24500 (83479) | 83479..84300 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| FYK42_RS24505 (84418) | 84418..84705 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| FYK42_RS24510 (84730) | 84730..84936 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| FYK42_RS24515 (85006) | 85006..85178 | + | 173 | Protein_101 | hypothetical protein | - |
| FYK42_RS24520 (85176) | 85176..85406 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| FYK42_RS24525 (85626) | 85626..85751 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| FYK42_RS24530 (85693) | 85693..85842 | - | 150 | Protein_104 | plasmid maintenance protein Mok | - |
| - (85828) | 85828..86052 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (85828) | 85828..86052 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (85828) | 85828..86052 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (85828) | 85828..86052 | - | 225 | NuclAT_0 | - | Antitoxin |
| FYK42_RS24535 (85864) | 85864..86052 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| FYK42_RS24540 (86021) | 86021..86783 | - | 763 | Protein_106 | plasmid SOS inhibition protein A | - |
| FYK42_RS24545 (86780) | 86780..87214 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| FYK42_RS24550 (87269) | 87269..87466 | - | 198 | Protein_108 | hypothetical protein | - |
| FYK42_RS24555 (87494) | 87494..87727 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| FYK42_RS24560 (87795) | 87795..88334 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| FYK42_RS24565 (88360) | 88360..88566 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| FYK42_RS24570 (88636) | 88636..88716 | + | 81 | Protein_112 | hypothetical protein | - |
| FYK42_RS24575 (88899) | 88899..89068 | - | 170 | Protein_113 | hypothetical protein | - |
| FYK42_RS24580 (89705) | 89705..90676 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-55 / cmlA1 / ARR-3 / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / ant(3'')-Ia / lnu(F) / sitABCD | iutA / iucD / iucC / iucB / iucB / iucA | 1..111058 | 111058 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T138255 WP_001372321.1 NZ_CP043286:c85751-85626 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T138255 NZ_CP057483:c3647030-3646623 [Citrobacter sp. RHB25-C09]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCATGGCGCGCGCAGTGGCTTTCATTGCTGCTTCATGGACTGGTTGCTGC
TGTAATACTGTTGATGCCCTGGCCGCTTAGCTATACACCGCTTTGGCTGATCCTGCTCTCGCTGGTCGTTTTTGATTGTG
TCCGCAGCCAGCGCCGTATCAACGCCTGTCAGGGAGAGGTGAAACTCCTGATGGACGGGCGACTACGTTGGCATGGACGT
GACTGGTCAATTGTGAGCGCGCCCTGGATTATCAAAAGTGGCATGATGCTCCGCCTGCGGTCAGATACAGGAAAGCGTCA
GCATTTATGGCTGGCGGCAGACAGCATGGATCAGACGGAGTGGCGGGATTTGTGTCGGCTGATGTTGCAGCCCTCAACGC
TGGGATAA
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCATGGCGCGCGCAGTGGCTTTCATTGCTGCTTCATGGACTGGTTGCTGC
TGTAATACTGTTGATGCCCTGGCCGCTTAGCTATACACCGCTTTGGCTGATCCTGCTCTCGCTGGTCGTTTTTGATTGTG
TCCGCAGCCAGCGCCGTATCAACGCCTGTCAGGGAGAGGTGAAACTCCTGATGGACGGGCGACTACGTTGGCATGGACGT
GACTGGTCAATTGTGAGCGCGCCCTGGATTATCAAAAGTGGCATGATGCTCCGCCTGCGGTCAGATACAGGAAAGCGTCA
GCATTTATGGCTGGCGGCAGACAGCATGGATCAGACGGAGTGGCGGGATTTGTGTCGGCTGATGTTGCAGCCCTCAACGC
TGGGATAA
Antitoxin
Download Length: 225 bp
>AT138255 NZ_CP043286:c86052-85828 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
