Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 735462..736155 Replicon chromosome
Accession NZ_CP043284
Organism Escherichia coli strain WCHEC025985

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag FYK42_RS03585 Protein ID WP_000415585.1
Coordinates 735462..735758 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYK42_RS03590 Protein ID WP_000650107.1
Coordinates 735760..736155 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK42_RS03550 (730596) 730596..731075 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
FYK42_RS03555 (731078) 731078..731788 + 711 WP_000834030.1 hypothetical protein -
FYK42_RS03560 (731795) 731795..732127 + 333 WP_000914690.1 DUF2645 family protein -
FYK42_RS03565 (732173) 732173..733522 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
FYK42_RS03570 (733519) 733519..734178 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
FYK42_RS03575 (734330) 734330..734722 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYK42_RS03580 (734775) 734775..735257 + 483 WP_000183505.1 GyrI-like domain-containing protein -
FYK42_RS03585 (735462) 735462..735758 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
FYK42_RS03590 (735760) 735760..736155 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYK42_RS03595 (736288) 736288..737895 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
FYK42_RS03600 (738033) 738033..740291 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T138231 WP_000415585.1 NZ_CP043284:735462-735758 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T138231 NZ_CP057464:2269-2544 [Escherichia fergusonii]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGACCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT138231 WP_000650107.1 NZ_CP043284:735760-736155 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT138231 NZ_CP057464:1985-2269 [Escherichia fergusonii]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References