Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721212..721905 Replicon chromosome
Accession NZ_CP043279
Organism Escherichia coli strain WCHEC025157

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYK41_RS03520 Protein ID WP_000415584.1
Coordinates 721212..721508 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYK41_RS03525 Protein ID WP_000650107.1
Coordinates 721510..721905 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK41_RS03485 (716300) 716300..716614 - 315 WP_000958598.1 putative quinol monooxygenase -
FYK41_RS03490 (716645) 716645..717226 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYK41_RS03495 (717545) 717545..717877 + 333 WP_000917685.1 DUF2645 family protein -
FYK41_RS03500 (717923) 717923..719272 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
FYK41_RS03505 (719269) 719269..719928 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
FYK41_RS03510 (720080) 720080..720472 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYK41_RS03515 (720525) 720525..721007 + 483 WP_000183505.1 GyrI-like domain-containing protein -
FYK41_RS03520 (721212) 721212..721508 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYK41_RS03525 (721510) 721510..721905 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYK41_RS03530 (722038) 722038..723645 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYK41_RS03535 (723783) 723783..726041 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T138198 WP_000415584.1 NZ_CP043279:721212-721508 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T138198 NZ_CP043279:721212-721508 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT138198 WP_000650107.1 NZ_CP043279:721510-721905 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT138198 NZ_CP057458:c3334849-3334556 [Escherichia fergusonii]
ATGCATCGAATTCTTGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATATTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGTCCATAAAGGCGCGTTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References