Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 29256..29520 | Replicon | plasmid pCMY42_035148 |
| Accession | NZ_CP043275 | ||
| Organism | Escherichia coli strain WCHEC035148 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | FYK53_RS22980 | Protein ID | WP_001387489.1 |
| Coordinates | 29256..29408 (-) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 29460..29520 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FYK53_RS22940 (24348) | 24348..24881 | - | 534 | WP_001221666.1 | lipocalin family protein | - |
| FYK53_RS22945 (24975) | 24975..26120 | - | 1146 | WP_039023136.1 | extended-spectrum class C beta-lactamase CMY-42 | - |
| FYK53_RS22955 (27325) | 27325..27423 | + | 99 | Protein_30 | ethanolamine utilization protein EutE | - |
| FYK53_RS22960 (27495) | 27495..27704 | - | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| FYK53_RS22965 (28096) | 28096..28272 | + | 177 | WP_001054897.1 | hypothetical protein | - |
| FYK53_RS24340 (28337) | 28337..28432 | - | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| FYK53_RS22975 (28933) | 28933..29184 | + | 252 | WP_001291964.1 | hypothetical protein | - |
| FYK53_RS22980 (29256) | 29256..29408 | - | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| - (29460) | 29460..29520 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (29460) | 29460..29520 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (29460) | 29460..29520 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (29460) | 29460..29520 | + | 61 | NuclAT_0 | - | Antitoxin |
| FYK53_RS22985 (29729) | 29729..30103 | + | 375 | WP_223349261.1 | hypothetical protein | - |
| FYK53_RS22990 (30256) | 30256..31413 | + | 1158 | Protein_37 | IS1380-like element ISEcp1 family transposase | - |
| FYK53_RS22995 (31469) | 31469..32166 | + | 698 | WP_095033700.1 | IS1-like element IS1B family transposase | - |
| FYK53_RS23000 (32177) | 32177..32485 | - | 309 | WP_039023235.1 | transcription termination/antitermination NusG family protein | - |
| FYK53_RS23005 (32927) | 32927..33214 | - | 288 | WP_000074855.1 | conjugal transfer protein TraA | - |
| FYK53_RS23010 (33252) | 33252..33410 | - | 159 | Protein_41 | ash family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCMY-42 | - | 1..34321 | 34321 | |
| - | inside | IScluster/Tn | blaCMY-42 | - | 24975..31744 | 6769 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T138184 WP_001387489.1 NZ_CP043275:c29408-29256 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T138184 NZ_CP043275:c29408-29256 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 61 bp
>AT138184 NZ_CP043275:29460-29520 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
