Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3866373..3866631 Replicon chromosome
Accession NZ_CP043274
Organism Escherichia coli strain WCHEC035148

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FYK53_RS18770 Protein ID WP_000809168.1
Coordinates 3866479..3866631 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3866373..3866430 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK53_RS18750 3861421..3862752 + 1332 Protein_3675 fimbria/pilus outer membrane usher protein -
FYK53_RS18755 3862765..3863723 + 959 Protein_3676 fimbrial family protein -
FYK53_RS18760 3863762..3864661 - 900 WP_001300855.1 transcriptional activator NhaR -
FYK53_RS18765 3864727..3865893 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3866373..3866430 - 58 - - Antitoxin
FYK53_RS18770 3866479..3866631 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FYK53_RS18775 3866735..3867865 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FYK53_RS18780 3867954..3869870 - 1917 WP_000516131.1 molecular chaperone DnaK -
FYK53_RS18785 3870247..3870651 + 405 WP_000843559.1 DUF2541 family protein -
FYK53_RS18790 3870677..3871390 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T138181 WP_000809168.1 NZ_CP043274:3866479-3866631 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T138181 NZ_CP043274:3866479-3866631 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT138181 NZ_CP043274:c3866430-3866373 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References