Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 768143..768836 Replicon chromosome
Accession NZ_CP043274
Organism Escherichia coli strain WCHEC035148

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag FYK53_RS03770 Protein ID WP_000415585.1
Coordinates 768143..768439 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYK53_RS03775 Protein ID WP_000650107.1
Coordinates 768441..768836 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK53_RS03735 (763277) 763277..763756 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
FYK53_RS03740 (763759) 763759..764469 + 711 WP_000834030.1 hypothetical protein -
FYK53_RS03745 (764476) 764476..764808 + 333 WP_000914690.1 DUF2645 family protein -
FYK53_RS03750 (764854) 764854..766203 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
FYK53_RS03755 (766200) 766200..766859 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
FYK53_RS03760 (767011) 767011..767403 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYK53_RS03765 (767456) 767456..767938 + 483 WP_000183505.1 GyrI-like domain-containing protein -
FYK53_RS03770 (768143) 768143..768439 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
FYK53_RS03775 (768441) 768441..768836 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYK53_RS03780 (768969) 768969..770576 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
FYK53_RS03785 (770714) 770714..772972 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T138166 WP_000415585.1 NZ_CP043274:768143-768439 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T138166 NZ_CP057353:1889760-1889863 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT138166 WP_000650107.1 NZ_CP043274:768441-768836 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT138166 NZ_CP057353:c1889869-1889634 [Citrobacter freundii]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCGACCAAAGTGG
CCTGAAAAAAAGGACGATTGTCACCCGCTAGAATGCAAAAACCGCAAGTTCTGCAGCCAGAACGTTGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References