Detailed information of TA system TA138157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 32160..32414
• Replicon: plasmid p1RM9973
• Accession: NZ_CP043273
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: FYK17_RS22965
• Protein ID: WP_207610778.1
• Coordinates: 32208..32414 (+)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	32160..32221 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS22945	29875..30621	+	747	WP_000205759.1	conjugal transfer pilus acetylase TraX	-
FYK17_RS22950	30676..31236	+	561	WP_001587438.1	fertility inhibition protein FinO	-
FYK17_RS22955	31372..31584	+	213	WP_001299730.1	ANR family transcriptional regulator	-
FYK17_RS22960	31830..31904	+	75	Protein_36	endonuclease	-
-	32160..32221	-	62	NuclAT_0	-	Antitoxin
-	32160..32221	-	62	NuclAT_0	-	Antitoxin
-	32160..32221	-	62	NuclAT_0	-	Antitoxin
-	32160..32221	-	62	NuclAT_0	-	Antitoxin
FYK17_RS22965	32208..32414	+	207	WP_207610778.1	Hok/Gef family protein	Toxin
FYK17_RS22970	32698..32955	+	258	WP_000083845.1	replication regulatory protein RepA	-
FYK17_RS22975	33187..33261	+	75	WP_001442103.1	RepA leader peptide Tap	-
FYK17_RS22980	33254..33736	+	483	WP_001523473.1	hypothetical protein	-
FYK17_RS22985	33729..34586	+	858	WP_207610779.1	incFII family plasmid replication initiator RepA	-
FYK17_RS22990	35659..35928	+	270	WP_071940833.1	hypothetical protein	-
FYK17_RS22995	35925..36140	+	216	WP_207610780.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FYK17_RS23000	36085..36207	+	123	WP_207610781.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..105082	105082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7838.37 Da
• Isoelectric Point: 8.8807

>T138157 WP_207610778.1 NZ_CP043273:32208-32414 [Escherichia albertii]
MKYLNTTDCSLFFAERSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVILAYEARK

Nucleotide

• Length: 207 bp

>T138157 NZ_CP057330:2253948-2254051 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin

Nucleotide

• Length: 62 bp

>AT138157 NZ_CP043273:c32221-32160 [Escherichia albertii]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCCTTTCT

Structures

Antitoxin