Detailed information of TA system TA138152

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-OrzO/SymE(toxin)
• Location: 4540218..4540630
• Replicon: chromosome
• Accession: NZ_CP043271
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A828GM97
• Locus tag: FYK17_RS21575
• Protein ID: WP_054409947.1
• Coordinates: 4540218..4540559 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	OrzO
Locus tag	-
Coordinates	4540554..4540630 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS21555	4535458..4536609	-	1152	WP_054409953.1	2-hydroxyacyl-CoA dehydratase subunit D	-
FYK17_RS21560	4536729..4538009	-	1281	WP_054409951.1	DUF445 domain-containing protein	-
FYK17_RS21565	4538196..4539128	+	933	WP_054409949.1	Rpn family recombination-promoting nuclease/putative transposase	-
FYK17_RS21570	4539314..4540171	+	858	Protein_4196	DUF1524 domain-containing protein	-
FYK17_RS21575	4540218..4540559	-	342	WP_054409947.1	endoribonuclease SymE	Toxin
-	4540554..4540630	+	77	NuclAT_8	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_8	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_8	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_8	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_9	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_9	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_9	-	Antitoxin
-	4540554..4540630	+	77	NuclAT_9	-	Antitoxin
FYK17_RS21580	4540774..4544037	-	3264	WP_207610379.1	HsdR family type I site-specific deoxyribonuclease	-
FYK17_RS21585	4544132..4545487	-	1356	WP_054409944.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12309.18 Da
• Isoelectric Point: 9.0984

>T138152 WP_054409947.1 NZ_CP043271:c4540559-4540218 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAIDVKVMEGCIVLTAQPPAAKESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T138152 NZ_CP057315:52840-53256 [Klebsiella pneumoniae]
GTGAAAAAGACTTTTATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGAGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGCCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT138152 NZ_CP043271:4540554-4540630 [Escherichia albertii]
AGTCATAACTGCTATTCCTTCGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A828GM97

Antitoxin