Detailed information of TA system TA138147

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3661294..3661551
• Replicon: chromosome
• Accession: NZ_CP043271
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: FYK17_RS17540
• Protein ID: WP_001135738.1
• Coordinates: 3661294..3661446 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3661497..3661551 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS17515	3657397..3658057	+	661	Protein_3418	OmpA family lipoprotein	-
FYK17_RS17520	3658161..3659135	+	975	WP_207610283.1	glyoxylate/hydroxypyruvate reductase GhrB	-
FYK17_RS17525	3659188..3659898	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
FYK17_RS17530	3660321..3660611	+	291	WP_000455794.1	HTH-type transcriptional regulator	-
FYK17_RS17535	3660894..3661106	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
FYK17_RS17540	3661294..3661446	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3661497..3661551	+	55	-	-	Antitoxin
FYK17_RS17545	3661769..3663838	-	2070	WP_059217117.1	glycine--tRNA ligase subunit beta	-
FYK17_RS17550	3663848..3664759	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
FYK17_RS17555	3664855..3665154	-	300	WP_000979961.1	YsaB family lipoprotein	-
FYK17_RS17560	3665327..3666322	+	996	WP_001182625.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T138147 WP_001135738.1 NZ_CP043271:c3661446-3661294 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T138147 NZ_CP043271:c3661446-3661294 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT138147 NZ_CP043271:3661497-3661551 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin