Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1511856..1512418 Replicon chromosome
Accession NZ_CP043271
Organism Escherichia albertii strain RM9973

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FYK17_RS07155 Protein ID WP_059277893.1
Coordinates 1512140..1512418 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8D9UMF3
Locus tag FYK17_RS07150 Protein ID WP_021528209.1
Coordinates 1511856..1512140 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK17_RS07135 1507038..1510085 + 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -
FYK17_RS07140 1510098..1510982 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
FYK17_RS07145 1510975..1511628 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
FYK17_RS07150 1511856..1512140 - 285 WP_021528209.1 HigA family addiction module antidote protein Antitoxin
FYK17_RS07155 1512140..1512418 - 279 WP_059277893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYK17_RS07160 1512604..1513382 - 779 Protein_1397 zinc-binding dehydrogenase -
FYK17_RS07165 1513517..1515214 - 1698 WP_000433487.1 malate dehydrogenase -
FYK17_RS07170 1515371..1515508 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
FYK17_RS07175 1515775..1516206 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.12 Da        Isoelectric Point: 8.0733

>T138135 WP_059277893.1 NZ_CP043271:c1512418-1512140 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCIADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GNAYILDYEDYH

Download         Length: 279 bp

>T138135 NZ_CP057311:4035689-4035991 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCACTCAACGCCACATAGAAA
GATTCCTGCTGAAATCCATACCACATTATCAAGAAAATTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTATTTAGATCCACACAACTACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.14 Da        Isoelectric Point: 8.8567

>AT138135 WP_021528209.1 NZ_CP043271:c1512140-1511856 [Escherichia albertii]
MKMVNHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT138135 NZ_CP057311:4036027-4036368 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAGCCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACAACTG
AAATGGCGTTTCGTCTGGCTAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCGGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACACAAGAAGAATTGGGACGGATTGAAACAGTGGCTGACTATTTGGCTCGCCGTGAAGA
GCGTGCAAAGAATGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References