Detailed information of TA system TA138132

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 15578..15836
• Replicon: chromosome
• Accession: NZ_CP043271
• Organism: Escherichia albertii strain RM9973

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: FYK17_RS00075
• Protein ID: WP_000809168.1
• Coordinates: 15578..15730 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	15779..15836 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK17_RS00055	10816..11529	-	714	WP_001102345.1	acidic protein MsyB	-
FYK17_RS00060	11556..11960	-	405	WP_000833521.1	DUF2541 family protein	-
FYK17_RS00065	12335..14251	+	1917	WP_207610385.1	molecular chaperone DnaK	-
FYK17_RS00070	14340..15470	+	1131	WP_001118445.1	molecular chaperone DnaJ	-
FYK17_RS00075	15578..15730	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	15779..15836	+	58	-	-	Antitoxin
FYK17_RS00080	16353..17114	+	762	WP_059273362.1	hypothetical protein	-
FYK17_RS00085	17135..18628	+	1494	WP_059216552.1	sulfatase-like hydrolase/transferase	-
FYK17_RS00090	18782..20029	+	1248	WP_105210836.1	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T138132 WP_000809168.1 NZ_CP043271:c15730-15578 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T138132 NZ_CP057311:c3440430-3439966 [Escherichia fergusonii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT138132 NZ_CP043271:15779-15836 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin