Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3885457..3885714 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag FYK18_RS19545 Protein ID WP_001135738.1
Coordinates 3885457..3885609 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3885666..3885714 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS19515 3881561..3882220 + 660 WP_000747625.1 OmpA family lipoprotein -
FYK18_RS19520 3882324..3883298 + 975 WP_059221283.1 glyoxylate/hydroxypyruvate reductase GhrB -
FYK18_RS19525 3883351..3884061 - 711 WP_002460072.1 DUF3053 domain-containing protein -
FYK18_RS19530 3884484..3884774 + 291 WP_059221281.1 HTH-type transcriptional regulator -
FYK18_RS19535 3885057..3885269 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
FYK18_RS19540 3885409..3885480 + 72 WP_212734940.1 hypothetical protein -
FYK18_RS19545 3885457..3885609 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 3885666..3885714 + 49 - - Antitoxin
FYK18_RS19550 3885997..3886455 - 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
FYK18_RS19555 3886642..3888711 - 2070 WP_059221279.1 glycine--tRNA ligase subunit beta -
FYK18_RS19560 3888721..3889632 - 912 WP_149534865.1 glycine--tRNA ligase subunit alpha -
FYK18_RS19565 3889728..3890027 - 300 WP_000979961.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3885997..3886455 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T138120 WP_001135738.1 NZ_CP043266:c3885609-3885457 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T138120 NZ_CP043266:c3885609-3885457 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 49 bp

>AT138120 NZ_CP043266:3885666-3885714 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References