Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3811575..3812287 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FYK18_RS19215 Protein ID WP_059220983.1
Coordinates 3811575..3811877 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYK18_RS19220 Protein ID WP_000806446.1
Coordinates 3811949..3812287 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS19200 (3808438) 3808438..3809280 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
FYK18_RS19205 (3809352) 3809352..3810704 + 1353 WP_054410173.1 glutathione-disulfide reductase -
FYK18_RS19210 (3810758) 3810758..3810841 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
FYK18_RS19215 (3811575) 3811575..3811877 + 303 WP_059220983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYK18_RS19220 (3811949) 3811949..3812287 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
FYK18_RS19225 (3812344) 3812344..3812523 + 180 WP_002460167.1 hypothetical protein -
FYK18_RS19230 (3812860) 3812860..3813426 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
FYK18_RS19235 (3813573) 3813573..3814103 + 531 WP_059220985.1 LuxR C-terminal-related transcriptional regulator -
FYK18_RS19240 (3814175) 3814175..3815203 - 1029 WP_001110409.1 hematinate-forming heme oxygenase ChuS -
FYK18_RS19245 (3815252) 3815252..3817234 - 1983 WP_059220987.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11885.61 Da        Isoelectric Point: 9.8664

>T138119 WP_059220983.1 NZ_CP043266:3811575-3811877 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNDYSSIRVNNQYR
LIFKWVNGKAEDLYLAPHKY

Download         Length: 303 bp

>T138119 NZ_CP057266:4096559-4096861 [Escherichia fergusonii]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCACTCAACGCCACATAGAAA
GATTCCTGCTGAAATCCATACCACATTATCAAGAAAATTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTATTTAGATCCACACAACTACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT138119 WP_000806446.1 NZ_CP043266:3811949-3812287 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT138119 NZ_CP057266:4096897-4097238 [Escherichia fergusonii]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAGCCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACAACTG
AAATGGCGTTTCGTCTGGCTAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCGGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACACAAGAAGAATTGGGACGGATTGAAACAGTGGCTGACTATTTGGCTCGCCGTGAAGA
GCGTGCAAAGAAGGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References