Detailed information of TA system TA138114

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2061428..2061653
• Replicon: chromosome
• Accession: NZ_CP043266
• Organism: Escherichia albertii strain RM9974

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: FYK18_RS10690
• Protein ID: WP_000813254.1
• Coordinates: 2061428..2061583 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2061595..2061653 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK18_RS10640	2056695..2056910	-	216	WP_000839596.1	phage lysis protein EssD	-
FYK18_RS10645	2057626..2058189	+	564	WP_024246368.1	DUF1440 domain-containing protein	-
FYK18_RS10670	2058873..2059562	-	690	WP_149508063.1	bacteriophage antitermination protein Q	-
FYK18_RS10675	2059559..2059924	-	366	WP_149508062.1	RusA family crossover junction endodeoxyribonuclease	-
FYK18_RS10680	2059925..2060980	-	1056	WP_059259435.1	DUF968 domain-containing protein	-
FYK18_RS10685	2060982..2061260	-	279	WP_149455594.1	hypothetical protein	-
FYK18_RS10690	2061428..2061583	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2061595..2061653	+	59	-	-	Antitoxin
FYK18_RS10695	2061795..2061923	-	129	WP_256876870.1	hypothetical protein	-
FYK18_RS10700	2062134..2062331	-	198	Protein_2092	DUF551 domain-containing protein	-
FYK18_RS10705	2062478..2062885	-	408	WP_137654438.1	hypothetical protein	-
FYK18_RS10710	2063044..2063460	-	417	WP_265451007.1	DUF977 family protein	-
FYK18_RS10715	2063468..2064229	-	762	WP_265451008.1	DUF1627 domain-containing protein	-
FYK18_RS10720	2064253..2064999	-	747	WP_113650040.1	ATP-binding protein	-
FYK18_RS10725	2065006..2065968	-	963	WP_161522641.1	helix-turn-helix domain-containing protein	-
FYK18_RS10730	2065992..2066417	-	426	WP_149535236.1	toxin YdaT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T138114 WP_000813254.1 NZ_CP043266:c2061583-2061428 [Escherichia albertii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T138114 NZ_CP057266:3377429-3377719 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACAAAATTA
AGCTTCGCACACTGGGATATCGCCGGGTCTATCAGGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT138114 NZ_CP043266:2061595-2061653 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin