Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1567915..1568477 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FYK18_RS08035 Protein ID WP_059278671.1
Coordinates 1568199..1568477 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag FYK18_RS08030 Protein ID WP_000781370.1
Coordinates 1567915..1568199 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS08015 (1563096) 1563096..1566143 + 3048 WP_077871680.1 formate dehydrogenase-N subunit alpha -
FYK18_RS08020 (1566156) 1566156..1567040 + 885 WP_059221881.1 formate dehydrogenase N subunit beta -
FYK18_RS08025 (1567033) 1567033..1567686 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
FYK18_RS08030 (1567915) 1567915..1568199 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
FYK18_RS08035 (1568199) 1568199..1568477 - 279 WP_059278671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYK18_RS08040 (1568663) 1568663..1569673 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
FYK18_RS08045 (1569808) 1569808..1571505 - 1698 WP_000433442.1 malate dehydrogenase -
FYK18_RS08050 (1571662) 1571662..1571799 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
FYK18_RS08055 (1572057) 1572057..1572488 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10480.14 Da        Isoelectric Point: 8.9374

>T138104 WP_059278671.1 NZ_CP043266:c1568477-1568199 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYKDYH

Download         Length: 279 bp

>T138104 NZ_CP057258:4393797-4394075 [Citrobacter freundii]
ATGAATAAACTTACTCGGTACGATCCCGCAACTGCGCTGGTTGATGATGAAGAAATTGCCGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAGCGTACATTGCAAAAGCCCTGGGCGTGGTGGCTCGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTTTATCGCTCTTTTAGTGAGAAAGGTAACCCAACGCTGAAAACTACGCTTGCAGTG
ATGAAGGCGCTCGGTATTGAATTGACACTTAAAAAATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT138104 WP_000781370.1 NZ_CP043266:c1568199-1567915 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT138104 NZ_CP057258:4393490-4393804 [Citrobacter freundii]
ATGGAAATTCTTCAGACAATGGTTTTCCAGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGCTAC
ACGCCTTTTTCGTTTGGCTAATGGTTTAGCTGGTGATGTCAAACCTGTTGGAGAAGGCATCAGCGAAATGCGCATTTCCT
ACGGTCCTGGTTACAGGATTTACTTTAAACAGCAAGGCTGCCACATCATCATTTTGTTATGTGGGGGCGATAAAAGCTCA
CAAGCCAACGATATCACTATGGCAAAAATGCTCGCCCGTTCACTGGATTATCAAGAGATCCGCCACCATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References