Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 16924..17182 Replicon chromosome
Accession NZ_CP043266
Organism Escherichia albertii strain RM9974

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FYK18_RS00080 Protein ID WP_000809168.1
Coordinates 16924..17076 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 17125..17182 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK18_RS00065 12336..14252 + 1917 WP_149535129.1 molecular chaperone DnaK -
FYK18_RS00070 14341..15471 + 1131 WP_001118445.1 molecular chaperone DnaJ -
FYK18_RS00075 15734..16846 - 1113 WP_265450788.1 IS4-like element IS421 family transposase -
FYK18_RS00080 16924..17076 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 17125..17182 + 58 - - Antitoxin
FYK18_RS00085 17698..18459 + 762 WP_001276206.1 outer membrane protein OmpK -
FYK18_RS00090 18480..19973 + 1494 WP_161522872.1 sulfatase-like hydrolase/transferase -
FYK18_RS00095 20127..21374 + 1248 WP_149534716.1 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T138100 WP_000809168.1 NZ_CP043266:c17076-16924 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T138100 NZ_CP043266:c17076-16924 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATAACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTCTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT138100 NZ_CP043266:17125-17182 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References