Detailed information of TA system TA138097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 132037..132458
• Replicon: plasmid p1RM9976
• Accession: NZ_CP043265
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: FYK19_RS26160
• Protein ID: WP_096937776.1
• Coordinates: 132333..132458 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	132037..132235 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS26120 (127259)	127259..127682	-	424	Protein_131	hypothetical protein	-
FYK19_RS26125 (127752)	127752..127958	+	207	WP_265463407.1	single-stranded DNA-binding protein	-
FYK19_RS26130 (127984)	127984..128517	+	534	WP_000290814.1	single-stranded DNA-binding protein	-
FYK19_RS26135 (128532)	128532..128798	+	267	WP_265463474.1	DUF905 family protein	-
FYK19_RS26140 (128862)	128862..130820	+	1959	WP_265463409.1	ParB/RepB/Spo0J family partition protein	-
FYK19_RS26145 (130875)	130875..131309	+	435	WP_001603648.1	conjugation system SOS inhibitor PsiB	-
FYK19_RS26150 (131306)	131306..132068	+	763	Protein_137	plasmid SOS inhibition protein A	-
- (132037)	132037..132235	+	199	NuclAT_0	-	Antitoxin
- (132037)	132037..132235	+	199	NuclAT_0	-	Antitoxin
- (132037)	132037..132235	+	199	NuclAT_0	-	Antitoxin
- (132037)	132037..132235	+	199	NuclAT_0	-	Antitoxin
FYK19_RS26155 (132242)	132242..132391	+	150	Protein_138	plasmid maintenance protein Mok	-
FYK19_RS26160 (132333)	132333..132458	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
FYK19_RS26165 (132759)	132759..133017	-	259	Protein_140	hypothetical protein	-
FYK19_RS26170 (133066)	133066..133285	+	220	Protein_141	hypothetical protein	-
FYK19_RS26175 (133404)	133404..134224	+	821	Protein_142	DUF932 domain-containing protein	-
FYK19_RS26180 (134520)	134520..135077	-	558	WP_262939981.1	transglycosylase SLT domain-containing protein	-
FYK19_RS26185 (135445)	135445..135828	+	384	WP_059257118.1	conjugal transfer relaxosome DNA-binding protein TraM	-
FYK19_RS26190 (136023)	136023..136694	+	672	WP_059257109.1	conjugal transfer transcriptional regulator TraJ	-
FYK19_RS26195 (136832)	136832..137059	+	228	WP_072247434.1	conjugal transfer relaxosome protein TraY	-
FYK19_RS26200 (137092)	137092..137451	+	360	WP_059257108.1	type IV conjugative transfer system pilin TraA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	cofA	1..200522	200522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T138097 WP_096937776.1 NZ_CP043265:132333-132458 [Escherichia albertii]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T138097 NZ_CP043265:132333-132458 [Escherichia albertii]
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 199 bp

>AT138097 NZ_CP043265:132037-132235 [Escherichia albertii]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTCTTTTCAGGAAAAGTGAGTGTGGTCAGCGCGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGCTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin