Detailed information of TA system TA138086

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-sib/SymE(toxin)
• Location: 4914429..4914841
• Replicon: chromosome
• Accession: NZ_CP043262
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: FYK19_RS24235
• Protein ID: WP_000132619.1
• Coordinates: 4914429..4914770 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	sib
Locus tag	-
Coordinates	4914765..4914841 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS24215 (4909460)	4909460..4910391	+	932	Protein_4725	Rpn family recombination-promoting nuclease/putative transposase	-
FYK19_RS24220 (4910708)	4910708..4911786	+	1079	Protein_4726	DUF1998 domain-containing protein	-
FYK19_RS24225 (4911842)	4911842..4912888	-	1047	WP_072252312.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
FYK19_RS24230 (4912888)	4912888..4914267	-	1380	WP_059217670.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FYK19_RS24235 (4914429)	4914429..4914770	-	342	WP_000132619.1	endoribonuclease SymE	Toxin
- (4914765)	4914765..4914841	+	77	NuclAT_10	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_10	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_10	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_10	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_9	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_9	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_9	-	Antitoxin
- (4914765)	4914765..4914841	+	77	NuclAT_9	-	Antitoxin
FYK19_RS24240 (4914999)	4914999..4916354	-	1356	WP_262939677.1	restriction endonuclease subunit S	-
FYK19_RS24245 (4916351)	4916351..4917940	-	1590	WP_157704341.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T138086 WP_000132619.1 NZ_CP043262:c4914770-4914429 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T138086 NZ_CP057256:c1036651-1036397 [Escherichia fergusonii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACTCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT138086 NZ_CP043262:4914765-4914841 [Escherichia albertii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin