Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3993254..3993511 Replicon chromosome
Accession NZ_CP043262
Organism Escherichia albertii strain RM9976

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag FYK19_RS19815 Protein ID WP_001135738.1
Coordinates 3993254..3993406 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3993457..3993511 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK19_RS19785 3989358..3990017 + 660 WP_000747625.1 OmpA family lipoprotein -
FYK19_RS19790 3990121..3991095 + 975 WP_000804993.1 glyoxylate/hydroxypyruvate reductase GhrB -
FYK19_RS19795 3991148..3991858 - 711 WP_002460072.1 DUF3053 domain-containing protein -
FYK19_RS19800 3992281..3992571 + 291 WP_000455794.1 HTH-type transcriptional regulator -
FYK19_RS19805 3992854..3993066 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
FYK19_RS19810 3993206..3993277 + 72 WP_212734940.1 hypothetical protein -
FYK19_RS19815 3993254..3993406 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 3993457..3993511 + 55 - - Antitoxin
FYK19_RS19820 3993729..3995798 - 2070 WP_001291807.1 glycine--tRNA ligase subunit beta -
FYK19_RS19825 3995808..3996719 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
FYK19_RS19830 3996815..3997114 - 300 WP_025238111.1 YsaB family lipoprotein -
FYK19_RS19835 3997287..3998282 + 996 WP_161537844.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T138083 WP_001135738.1 NZ_CP043262:c3993406-3993254 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T138083 NZ_CP043262:c3993406-3993254 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT138083 NZ_CP043262:3993457-3993511 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References