Detailed information of TA system TA138077

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2504318..2504543
• Replicon: chromosome
• Accession: NZ_CP043262
• Organism: Escherichia albertii strain RM9976

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: FYK19_RS12280
• Protein ID: WP_000813254.1
• Coordinates: 2504318..2504473 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2504485..2504543 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK19_RS12235	2499414..2500193	-	780	WP_059214840.1	ParB/Srx family N-terminal domain-containing protein	-
FYK19_RS12240	2500479..2500757	-	279	WP_233991579.1	hypothetical protein	-
FYK19_RS12245	2500642..2501034	-	393	WP_059214839.1	DUF2570 domain-containing protein	-
FYK19_RS12250	2501018..2501494	-	477	WP_001194114.1	glycoside hydrolase family protein	-
FYK19_RS12255	2501498..2501833	-	336	WP_001766841.1	phage holin, lambda family	-
FYK19_RS12260	2502331..2502873	-	543	WP_059214837.1	DUF1133 family protein	-
FYK19_RS12265	2502870..2503111	-	242	Protein_2400	DUF1364 domain-containing protein	-
FYK19_RS12270	2503159..2503758	-	600	WP_059214836.1	DUF1367 family protein	-
FYK19_RS12275	2503830..2504042	-	213	WP_072248386.1	hypothetical protein	-
FYK19_RS12280	2504318..2504473	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2504485..2504543	+	59	-	-	Antitoxin
FYK19_RS12285	2505020..2505571	-	552	WP_233991578.1	DUF551 domain-containing protein	-
FYK19_RS12290	2505573..2506001	-	429	WP_233991577.1	hypothetical protein	-
FYK19_RS12295	2506132..2506434	-	303	WP_233991594.1	hypothetical protein	-
FYK19_RS12300	2506430..2506694	-	265	Protein_2407	hypothetical protein	-
FYK19_RS12305	2506691..2507107	-	417	WP_059224269.1	DUF977 family protein	-
FYK19_RS12310	2507115..2507876	-	762	WP_233991576.1	DUF1627 domain-containing protein	-
FYK19_RS12315	2507900..2508646	-	747	WP_262939501.1	ATP-binding protein	-
FYK19_RS12320	2508653..2509441	-	789	WP_059224271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T138077 WP_000813254.1 NZ_CP043262:c2504473-2504318 [Escherichia albertii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T138077 NZ_CP043262:c2504473-2504318 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT138077 NZ_CP043262:2504485-2504543 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin