Detailed information of TA system TA138055

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 4905459..4905871
• Replicon: chromosome
• Accession: NZ_CP043258
• Organism: Escherichia albertii strain RM10507

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7L6L4L5
• Locus tag: FYK20_RS24185
• Protein ID: WP_033873755.1
• Coordinates: 4905459..4905800 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4905795..4905871 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK20_RS24165 (4900738)	4900738..4901889	-	1152	WP_054409953.1	double-cubane-cluster-containing anaerobic reductase	-
FYK20_RS24170 (4902009)	4902009..4903289	-	1281	WP_059273481.1	DUF445 domain-containing protein	-
FYK20_RS24175 (4903476)	4903476..4904372	+	897	WP_265464088.1	Rpn family recombination-promoting nuclease/putative transposase	-
FYK20_RS24180 (4904558)	4904558..4905412	+	855	Protein_4706	DUF1524 domain-containing protein	-
FYK20_RS24185 (4905459)	4905459..4905800	-	342	WP_033873755.1	endoribonuclease SymE	Toxin
- (4905795)	4905795..4905871	+	77	NuclAT_5	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_5	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_5	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_5	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_6	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_6	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_6	-	Antitoxin
- (4905795)	4905795..4905871	+	77	NuclAT_6	-	Antitoxin
FYK20_RS24190 (4906015)	4906015..4909278	-	3264	WP_149477518.1	HsdR family type I site-specific deoxyribonuclease	-
FYK20_RS24195 (4909373)	4909373..4910743	-	1371	WP_000527982.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12296.10 Da
• Isoelectric Point: 7.8219

>T138055 WP_033873755.1 NZ_CP043258:c4905800-4905459 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T138055 NZ_CP057239:133550-133966 [Escherichia fergusonii]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGGCGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT138055 NZ_CP043258:4905795-4905871 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A7L6L4L5

Antitoxin