Detailed information of TA system TA138054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 3897200..3897912
• Replicon: chromosome
• Accession: NZ_CP043258
• Organism: Escherichia albertii strain RM10507

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7U8WCQ7
• Locus tag: FYK20_RS19390
• Protein ID: WP_000162413.1
• Coordinates: 3897200..3897502 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYK20_RS19395
• Protein ID: WP_000806446.1
• Coordinates: 3897574..3897912 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYK20_RS19360 (3892762)	3892762..3893604	+	843	WP_000954227.1	23S rRNA (adenine(2030)-N(6))-methyltransferase	-
FYK20_RS19365 (3893676)	3893676..3895028	+	1353	WP_000160823.1	glutathione-disulfide reductase	-
FYK20_RS19370 (3895079)	3895079..3895165	-	87	WP_265464700.1	damage-inducible type I toxin DinQ	-
FYK20_RS19375 (3895193)	3895193..3895366	+	174	WP_044708027.1	hypothetical protein	-
FYK20_RS19380 (3895462)	3895462..3896544	+	1083	WP_265463928.1	IS481 family transposase	-
FYK20_RS19385 (3896746)	3896746..3897036	-	291	WP_113650513.1	hypothetical protein	-
FYK20_RS19390 (3897200)	3897200..3897502	+	303	WP_000162413.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYK20_RS19395 (3897574)	3897574..3897912	+	339	WP_000806446.1	HigA family addiction module antitoxin	Antitoxin
FYK20_RS19400 (3897969)	3897969..3898148	+	180	WP_059219034.1	hypothetical protein	-
FYK20_RS19405 (3898495)	3898495..3899061	+	567	WP_059216822.1	outer membrane lipoprotein Slp	-
FYK20_RS19410 (3899208)	3899208..3899738	+	531	WP_000480294.1	LuxR C-terminal-related transcriptional regulator	-
FYK20_RS19415 (3899810)	3899810..3900838	-	1029	WP_001110409.1	hematinate-forming heme oxygenase ChuS	-
FYK20_RS19420 (3900887)	3900887..3902869	-	1983	WP_000089601.1	TonB-dependent heme/hemoglobin receptor ChuA/ShuA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3895462..3896544	1082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (6-100)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-100)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11871.59 Da
• Isoelectric Point: 9.8664

>T138054 WP_000162413.1 NZ_CP043258:3897200-3897502 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Nucleotide

• Length: 303 bp

>T138054 NZ_CP043258:3897200-3897502 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAAGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 13037.92 Da
• Isoelectric Point: 5.2075

>AT138054 WP_000806446.1 NZ_CP043258:3897574-3897912 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Nucleotide

• Length: 339 bp

>AT138054 NZ_CP057239:c132736-132518 [Escherichia fergusonii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCCAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U8WCQ7