Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1616369..1616931 Replicon chromosome
Accession NZ_CP043258
Organism Escherichia albertii strain RM10507

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag FYK20_RS07965 Protein ID WP_000605679.1
Coordinates 1616653..1616931 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag FYK20_RS07960 Protein ID WP_000781370.1
Coordinates 1616369..1616653 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK20_RS07945 (1611551) 1611551..1614598 + 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -
FYK20_RS07950 (1614611) 1614611..1615495 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
FYK20_RS07955 (1615488) 1615488..1616141 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
FYK20_RS07960 (1616369) 1616369..1616653 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
FYK20_RS07965 (1616653) 1616653..1616931 - 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYK20_RS07970 (1617117) 1617117..1617631 - 515 Protein_1554 alcohol dehydrogenase catalytic domain-containing protein -
FYK20_RS07975 (1617766) 1617766..1619463 - 1698 WP_059259313.1 malate dehydrogenase -
FYK20_RS07980 (1619620) 1619620..1619757 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
FYK20_RS07985 (1620015) 1620015..1620446 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T138040 WP_000605679.1 NZ_CP043258:c1616931-1616653 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T138040 NZ_CP057238:236398-236501 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT138040 WP_000781370.1 NZ_CP043258:c1616653-1616369 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT138040 NZ_CP057238:c236537-236272 [Escherichia fergusonii]
AGTCAGCGAAGGGAATTTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATG
GCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGAC
GCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTC
TGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References