Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2232551..2233244 Replicon chromosome
Accession NZ_CP043227
Organism Escherichia coli strain Ec-050

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FX998_RS10915 Protein ID WP_000415584.1
Coordinates 2232948..2233244 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FX998_RS10910 Protein ID WP_000650107.1
Coordinates 2232551..2232946 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX998_RS10900 2228415..2230673 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
FX998_RS10905 2230811..2232418 - 1608 WP_087523553.1 ABC transporter substrate-binding protein -
FX998_RS10910 2232551..2232946 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FX998_RS10915 2232948..2233244 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FX998_RS10920 2233449..2233931 - 483 WP_000183505.1 transcriptional regulator -
FX998_RS10925 2233984..2234376 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FX998_RS10930 2234528..2235187 + 660 WP_001221493.1 two-component system response regulator QseB -
FX998_RS10935 2235184..2236533 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FX998_RS10940 2236579..2236911 - 333 WP_000917685.1 DUF2645 family protein -
FX998_RS10945 2237230..2237811 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FX998_RS10950 2237842..2238156 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T138009 WP_000415584.1 NZ_CP043227:c2233244-2232948 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T138009 NZ_CP057220:1988831-1988934 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT138009 WP_000650107.1 NZ_CP043227:c2232946-2232551 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT138009 NZ_CP043227:c2232946-2232551 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References