Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2359915..2360642 Replicon chromosome
Accession NZ_CP043217
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag FYA02_RS11920 Protein ID WP_000550189.1
Coordinates 2360328..2360642 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYA02_RS11915 Protein ID WP_000560255.1
Coordinates 2359915..2360331 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS11905 2355075..2357426 + 2352 WP_000695486.1 alpha-glucosidase -
FYA02_RS11910 2357852..2359870 + 2019 WP_000121433.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
FYA02_RS11915 2359915..2360331 - 417 WP_000560255.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FYA02_RS11920 2360328..2360642 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
FYA02_RS11925 2360926..2362062 - 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
FYA02_RS11930 2362147..2362650 + 504 WP_001300832.1 M48 family metallopeptidase -
FYA02_RS11935 2362727..2363419 + 693 WP_000942548.1 vancomycin high temperature exclusion protein -
FYA02_RS11940 2363498..2364484 + 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T137951 WP_000550189.1 NZ_CP043217:c2360642-2360328 [Escherichia coli O80:H26]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T137951 NZ_CP057150:c2658191-2658088 [Citrobacter sp. RHB35-C17]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14951.41 Da        Isoelectric Point: 4.5577

>AT137951 WP_000560255.1 NZ_CP043217:c2360331-2359915 [Escherichia coli O80:H26]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNAPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT137951 NZ_CP057150:2658084-2658231 [Citrobacter sp. RHB35-C17]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References