Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2295375..2296068 Replicon chromosome
Accession NZ_CP043217
Organism Escherichia coli O80:H26 strain EC-107

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYA02_RS11620 Protein ID WP_000415584.1
Coordinates 2295772..2296068 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYA02_RS11615 Protein ID WP_000650107.1
Coordinates 2295375..2295770 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA02_RS11605 2291239..2293497 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
FYA02_RS11610 2293635..2295242 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYA02_RS11615 2295375..2295770 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYA02_RS11620 2295772..2296068 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYA02_RS11625 2296273..2296755 - 483 WP_000183505.1 transcriptional regulator -
FYA02_RS11630 2296808..2297200 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYA02_RS11635 2297352..2298011 + 660 WP_032205041.1 two-component system response regulator QseB -
FYA02_RS11640 2298008..2299357 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FYA02_RS11645 2299403..2299735 - 333 WP_000917684.1 DUF2645 family protein -
FYA02_RS11650 2300054..2300635 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYA02_RS11655 2300666..2300980 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T137950 WP_000415584.1 NZ_CP043217:c2296068-2295772 [Escherichia coli O80:H26]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T137950 NZ_CP057150:2284672-2284950 [Citrobacter sp. RHB35-C17]
ATGATCATGAATTTCAGGCACAAGGGATTACGCGACCTGTTTCTTCACGGTAAAACGTCAGGCGTGCTGGCAAAGCACGT
CAAACGTTTGCGACACCGCCTCGCCGTGATTGACGCCGCAGGCTGCGTGAACGATATCAACATGCCCGGTTATCGGCTGC
ATCCTCTGAGCGGCGATCGTGATGGCGTCTGGTCAATATCGGTTTCAGACAACTGGCGTATGACGTTCGAATTTGTCAAT
GGCGATGCGTATATTCTGGATTACGAGGATTATCACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT137950 WP_000650107.1 NZ_CP043217:c2295770-2295375 [Escherichia coli O80:H26]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT137950 NZ_CP057150:2284950-2285234 [Citrobacter sp. RHB35-C17]
ATGAAAATGGCGAATCATCCCCGCCCAGGGGATATCATTCAGGAAGCGCTGGACGAACTGAACGTCAGTTTGCGTGAATT
TGCCAGAGCAATGGAGATTGCGCCCTCAACCGCCAGCCGTTTACTCACGGGCAAAGCGGCACTCACCCCGGAAATGGCGA
TCAAACTCTCGGTGGTGATCGGCAGCTCCCCGGAAATGTGGCTAAATCTGCAAAATACCTGGAGTCTGGCACAAGCGCAA
AAAAGCGTGGACGTGTCCCGCCTGCGCCGTCTGGCGGTGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References