Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3635708..3636401 Replicon chromosome
Accession NZ_CP043213
Organism Escherichia coli O16:H48 strain CV601gfp

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYA04_RS17775 Protein ID WP_000415584.1
Coordinates 3636105..3636401 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYA04_RS17770 Protein ID WP_000650107.1
Coordinates 3635708..3636103 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA04_RS17760 3631572..3633830 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
FYA04_RS17765 3633968..3635575 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYA04_RS17770 3635708..3636103 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYA04_RS17775 3636105..3636401 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYA04_RS17780 3636606..3637088 - 483 WP_000183505.1 transcriptional regulator -
FYA04_RS17785 3637141..3637533 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYA04_RS17790 3637685..3638344 + 660 WP_001221495.1 two-component system response regulator QseB -
FYA04_RS17795 3638341..3639690 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FYA04_RS17800 3639736..3640068 - 333 WP_000917684.1 DUF2645 family protein -
FYA04_RS17805 3640387..3640968 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYA04_RS17810 3640999..3641313 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T137928 WP_000415584.1 NZ_CP043213:c3636401-3636105 [Escherichia coli O16:H48]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T137928 NZ_CP057136:c2949373-2949270 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT137928 WP_000650107.1 NZ_CP043213:c3636103-3635708 [Escherichia coli O16:H48]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT137928 NZ_CP057136:2949264-2949499 [Citrobacter freundii]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGTCCGCGACCAAAGTGG
CCTGAAAAAAAGGACGATTGTCACCCGCTAGAATGCAAAAACCGCAAGTTCTGCAGCCAGAACGTTGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References