Detailed information of TA system TA137907

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1884075..1884446
• Replicon: chromosome
• Accession: NZ_CP043213
• Organism: Escherichia coli O16:H48 strain CV601gfp

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: FYA04_RS09300
• Protein ID: WP_001317028.1
• Coordinates: 1884252..1884446 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1884075..1884253 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA04_RS09275	1880030..1881403	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
FYA04_RS09280	1881532..1882467	-	936	WP_001157406.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
FYA04_RS09285	1882519..1883754	-	1236	WP_000040852.1	site-specific integrase	-
FYA04_RS09290	1883756..1883971	-	216	WP_000079604.1	excisionase XisR	-
FYA04_RS09295	1884050..1884259	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	1884075..1884253	+	179	NuclAT_0	-	Antitoxin
-	1884075..1884253	+	179	NuclAT_0	-	Antitoxin
-	1884075..1884253	+	179	NuclAT_0	-	Antitoxin
-	1884075..1884253	+	179	NuclAT_0	-	Antitoxin
FYA04_RS09300	1884252..1884446	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
FYA04_RS09305	1884503..1885312	-	810	WP_000166319.1	recombination protein RecT	-
FYA04_RS09310	1885305..1887905	-	2601	WP_000105143.1	exodeoxyribonuclease VIII	-
FYA04_RS09315	1888007..1888282	-	276	WP_000632297.1	protein RacC	-
FYA04_RS09320	1888357..1888527	-	171	WP_001352098.1	conserved protein, Rac prophage	-
FYA04_RS09325	1888527..1888748	-	222	WP_000560225.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1851340..1904193	52853

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T137907 WP_001317028.1 NZ_CP043213:c1884446-1884252 [Escherichia coli O16:H48]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T137907 NZ_CP057104:c4314158-4314051 [Escherichia fergusonii]
ATGACGCTCGCTGAGTTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATCGCTGGCATTCTTGCCAGTTTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT137907 NZ_CP043213:1884075-1884253 [Escherichia coli O16:H48]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin