Detailed information of TA system TA137883

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4244762..4245174
• Replicon: chromosome
• Accession: NZ_CP043211
• Organism: Escherichia coli O16:H48 strain PG20180050

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: FYA05_RS20760
• Protein ID: WP_000132601.1
• Coordinates: 4244833..4245174 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4244762..4244838 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA05_RS20750	4241625..4243214	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
FYA05_RS20755	4243211..4244605	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	4244762..4244838	-	77	NuclAT_14	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_14	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_14	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_14	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_15	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_15	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_15	-	Antitoxin
-	4244762..4244838	-	77	NuclAT_15	-	Antitoxin
FYA05_RS20760	4244833..4245174	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
FYA05_RS20765	4245336..4246715	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FYA05_RS20770	4246715..4247761	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T137883 WP_000132601.1 NZ_CP043211:4244833-4245174 [Escherichia coli O16:H48]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T137883 NZ_CP057101:1983451-1983554 [Escherichia fergusonii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 77 bp

>AT137883 NZ_CP043211:c4244838-4244762 [Escherichia coli O16:H48]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin