Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2078165..2078667 | Replicon | chromosome |
Accession | NZ_CP043211 | ||
Organism | Escherichia coli O16:H48 strain PG20180050 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | FYA05_RS09835 | Protein ID | WP_000767829.1 |
Coordinates | 2078413..2078667 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | FYA05_RS09830 | Protein ID | WP_001259255.1 |
Coordinates | 2078165..2078416 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FYA05_RS09805 | 2073343..2074410 | - | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
FYA05_RS09810 | 2074410..2075480 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
FYA05_RS09815 | 2075477..2076781 | - | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
FYA05_RS09820 | 2076787..2077686 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
FYA05_RS09825 | 2077832..2077882 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
FYA05_RS09830 | 2078165..2078416 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
FYA05_RS09835 | 2078413..2078667 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
FYA05_RS09840 | 2078750..2079574 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
FYA05_RS09845 | 2079620..2080549 | + | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
FYA05_RS09850 | 2080764..2080826 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
FYA05_RS09855 | 2080816..2082174 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
FYA05_RS09860 | 2082353..2083411 | + | 1059 | WP_000492339.1 | transport protein YeeE | - |
FYA05_RS09865 | 2083425..2083652 | + | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T137866 WP_000767829.1 NZ_CP043211:2078413-2078667 [Escherichia coli O16:H48]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T137866 NZ_CP043211:2078413-2078667 [Escherichia coli O16:H48]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT137866 WP_001259255.1 NZ_CP043211:2078165-2078416 [Escherichia coli O16:H48]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT137866 NZ_CP043211:2078165-2078416 [Escherichia coli O16:H48]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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