Detailed information of TA system TA137817

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3959786..3960198
• Replicon: chromosome
• Accession: NZ_CP043207
• Organism: Escherichia coli O16:H48 strain PG20180053

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: FYA07_RS19425
• Protein ID: WP_000132601.1
• Coordinates: 3959857..3960198 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3959786..3959862 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA07_RS19415	3956649..3958238	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
FYA07_RS19420	3958235..3959629	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	3959786..3959862	-	77	NuclAT_14	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_14	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_14	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_14	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_15	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_15	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_15	-	Antitoxin
-	3959786..3959862	-	77	NuclAT_15	-	Antitoxin
FYA07_RS19425	3959857..3960198	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
FYA07_RS19430	3960360..3961739	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FYA07_RS19435	3961739..3962785	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T137817 WP_000132601.1 NZ_CP043207:3959857-3960198 [Escherichia coli O16:H48]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T137817 NZ_CP057034:c5105929-5105546 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT137817 NZ_CP043207:c3959862-3959786 [Escherichia coli O16:H48]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin